Friend leukemia: rapid development of erythropoietin-independent hematopoietic precursors
- PMID: 1054098
- DOI: 10.1093/jnci/54.1.265
Friend leukemia: rapid development of erythropoietin-independent hematopoietic precursors
Abstract
Infection of mice with the polycythemia-inducing strain of Friend leukemia virus caused a rapid emergence of new erythroid precursor cells. These cells which, in the absence of erythropoietin, proliferated in vitro to form colonies and even differnetiated, quickly out-numbered the usual erythropoietin-dependent hematopoietic elements in bone marrow and spleen. Ultimately, the marrow and spleen were probably totally repopulated with this erythropoietin-independent cell.
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