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. 1975 Jan;54(1):265-7.
doi: 10.1093/jnci/54.1.265.

Friend leukemia: rapid development of erythropoietin-independent hematopoietic precursors

J S Horoszewicz, S S Leong, W A Carter

Friend leukemia: rapid development of erythropoietin-independent hematopoietic precursors

J S Horoszewicz et al. J Natl Cancer Inst. 1975 Jan.

Abstract

Infection of mice with the polycythemia-inducing strain of Friend leukemia virus caused a rapid emergence of new erythroid precursor cells. These cells which, in the absence of erythropoietin, proliferated in vitro to form colonies and even differnetiated, quickly out-numbered the usual erythropoietin-dependent hematopoietic elements in bone marrow and spleen. Ultimately, the marrow and spleen were probably totally repopulated with this erythropoietin-independent cell.

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