[Effect of polychlorinated biphenyls in the rat. IV - Metabolic alterations and residual effects of DP6 dietary exposure (author's transl)]

Abstract

In the first experiment, rats fed diet containing Phenoclor DP6 at a level of 100 ppm (wet weigh) were sacrificed after 1, 3, 8, 15 and 30 days of treatment. Metabolic alterations such as enlarged liver, increased protein and lipid liver contents and hyperlipemia were established within 8 days. The glucid metabolism and muscle metabolic parameters show a low sensibility to DP6 treatment. In the second experiment, rats fed diet containing Phenoclor DP6 (100 ppm) for 15 days were subsequently removed from the experimental diet and placed on control diet. The metabolic alterations described above disappear within 52 days after removal DP6 diet, although the remaining liver PCB stays elevated. These data attest the early effect of DP6 exposure in rats and the reversibility of induced metabolic alterations.