In vitro susceptibilities of Neisseria gonorrhoeae to fatty acids and monoglycerides

doi:10.1128/AAC.43.11.2790

. 1999 Nov;43(11):2790-2.

doi: 10.1128/AAC.43.11.2790.

In vitro susceptibilities of Neisseria gonorrhoeae to fatty acids and monoglycerides

G Bergsson¹, O Steingrímsson, H Thormar

Affiliations

PMID: 10543766
PMCID: PMC89562
DOI: 10.1128/AAC.43.11.2790

In vitro susceptibilities of Neisseria gonorrhoeae to fatty acids and monoglycerides

G Bergsson et al. Antimicrob Agents Chemother. 1999 Nov.

. 1999 Nov;43(11):2790-2.

doi: 10.1128/AAC.43.11.2790.

Authors

G Bergsson¹, O Steingrímsson, H Thormar

Affiliation

¹ Institute of Biology, University of Iceland. gudmunb@rhi.hi.is

PMID: 10543766
PMCID: PMC89562
DOI: 10.1128/AAC.43.11.2790

Abstract

The susceptibility of Neisseria gonorrhoeae to several medium-chain fatty acids and their 1-monoglycerides was tested at a short inactivation time of 1 min. The results indicate that monocaprin, a monoglyceride of capric acid (10 carbon atoms, no double bonds), causes the fastest and most effective killing of all strains of N. gonorrhoeae tested.

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Figures

**FIG. 1**
Inactivation of *N. gonorrhoeae* by incubation with 2.5 mM solutions of fatty acids and monoglycerides for 1 min at room temperature. The bars represent reduction of CFU. In the bars, the asterisks indicate that the reduction of titer was equal to or greater than 6.0 log₁₀ CFU. Caprylic acid and monocaprylin (8:0) (number of carbon atoms/number of double bonds), capric acid and monocaprin (10:0), lauric acid and monolaurin (12:0), myristic acid and monomyristin (14:0), palmitoleic acid and monopalmitolein (16:1), and oleic acid and monoolein (18:1) are shown.

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References

1. Australian Gonococcal Surveillance Programme. Annual report 1997. Commun Dis Intell. 1998;22:212–216. - PubMed
1. Bergsson G, Arnfinnsson J, Karlsson S M, Steingrímsson Ó, Thormar H. In vitro inactivation of Chlamydia trachomatis by fatty acids and monoglycerides. Antimicrob Agents Chemother. 1998;42:2290–2294. - PMC - PubMed
1. Bergsson G, Steingrímsson Ó, Thormar H. Microbicidal effect of lipids against gram-positive and gram-negative cocci. Icelandic Med J. 1998;84(Suppl. 37):118.
1. Bjekic M, Vlajinac H, Sipetic S. Incidence of gonorrhea in Belgrade, 1988–1994. J Infect. 1998;37:44–47. - PubMed
1. Elias C J, Heise L L. Challenges for the development of female-controlled vaginal microbicides. AIDS. 1994;8:1–9. - PubMed

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[1] Australian Gonococcal Surveillance Programme. Annual report 1997. Commun Dis Intell. 1998;22:212–216. - PubMed

[2] Australian Gonococcal Surveillance Programme. Annual report 1997. Commun Dis Intell. 1998;22:212–216. - PubMed

[3] Bergsson G, Arnfinnsson J, Karlsson S M, Steingrímsson Ó, Thormar H. In vitro inactivation of Chlamydia trachomatis by fatty acids and monoglycerides. Antimicrob Agents Chemother. 1998;42:2290–2294. - PMC - PubMed

[4] Bergsson G, Arnfinnsson J, Karlsson S M, Steingrímsson Ó, Thormar H. In vitro inactivation of Chlamydia trachomatis by fatty acids and monoglycerides. Antimicrob Agents Chemother. 1998;42:2290–2294. - PMC - PubMed

[5] Bergsson G, Steingrímsson Ó, Thormar H. Microbicidal effect of lipids against gram-positive and gram-negative cocci. Icelandic Med J. 1998;84(Suppl. 37):118.

[6] Bergsson G, Steingrímsson Ó, Thormar H. Microbicidal effect of lipids against gram-positive and gram-negative cocci. Icelandic Med J. 1998;84(Suppl. 37):118.

[7] Bjekic M, Vlajinac H, Sipetic S. Incidence of gonorrhea in Belgrade, 1988–1994. J Infect. 1998;37:44–47. - PubMed

[8] Bjekic M, Vlajinac H, Sipetic S. Incidence of gonorrhea in Belgrade, 1988–1994. J Infect. 1998;37:44–47. - PubMed

[9] Elias C J, Heise L L. Challenges for the development of female-controlled vaginal microbicides. AIDS. 1994;8:1–9. - PubMed

[10] Elias C J, Heise L L. Challenges for the development of female-controlled vaginal microbicides. AIDS. 1994;8:1–9. - PubMed

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In vitro susceptibilities of Neisseria gonorrhoeae to fatty acids and monoglycerides

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In vitro susceptibilities of Neisseria gonorrhoeae to fatty acids and monoglycerides

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