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. 1975 Jan;72(1):103-7.
doi: 10.1073/pnas.72.1.103.

Xeroderma pigmentosum cells contain low levels of photoreactivating enzyme

B M Sutherland, M Rice, E K Wagner

Xeroderma pigmentosum cells contain low levels of photoreactivating enzyme

B M Sutherland et al. Proc Natl Acad Sci U S A. 1975 Jan.

Abstract

Fibroblasts from patients with xeroderma pigmentosum contain low levels of photoreactivating enzyme in comparison to normal cells. Levels vary from 0 (line 1199) to 50 (line 1259) percent of normal. The depressed enzyme levels are not an artifact of low growth rate, age of cell donor, cell culture conditions, assay conditions, the presence of inhibitors, or mycoplasma contamination. We show that human fibroblasts can monomerize pyrimidine dimers in vivo.

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