Follicular dendritic cells and T cells: nurses and executioners in the germinal centre reaction
- PMID: 10547566
- DOI: 10.1002/(SICI)1096-9896(199910)189:2<147::AID-PATH433>3.0.CO;2-8
Follicular dendritic cells and T cells: nurses and executioners in the germinal centre reaction
Abstract
The humoral immune response constitutes an efficient system to protect the organism against diseases caused by invading pathogens. To guarantee a highly efficient defence, the humoral immune system has to be tightly regulated. Two cell subsets in particular, T cells and follicular dendritic cells (FDCs), contribute to the success of these regulation processes. Whereas the particular role of T cells is the elimination of autoreactive clones, the main role of FDCs is to present unprocessed antigen and check B-cell clones for higher affinity. B-cell clones unsuited for improved humoral immune response will be specifically killed. Involvement of Fas-mediated apoptosis might be an additional tool not only in T-cell-mediated regulation, but also in FDC-B cell interaction in the germinal centre.
Copyright 1999 John Wiley & Sons, Ltd.
Comment on
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Fas ligand expression in the germinal centre.J Pathol. 1999 Oct;189(2):155-60. doi: 10.1002/(SICI)1096-9896(199910)189:2<155::AID-PATH442>3.0.CO;2-9. J Pathol. 1999. PMID: 10547568
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