doi: 10.1073/pnas.72.2.628.
X-ray crystallographic visualization of drug-nucleic acid intercalative binding: structure of an ethidium-dinucleoside monophosphate crystalline complex, Ethidium: 5-iodouridylyl (3'-5') adenosine
- PMID: 1054844
- PMCID: PMC432367
- DOI: 10.1073/pnas.72.2.628
Item in Clipboard
X-ray crystallographic visualization of drug-nucleic acid intercalative binding: structure of an ethidium-dinucleoside monophosphate crystalline complex, Ethidium: 5-iodouridylyl (3'-5') adenosine
Proc Natl Acad Sci U S A.
1975 Feb.
Abstract
We have cocrystallized the drug ethidium bromide with the dinucleoside monophosphate 5-iodouridylyl(3'-5')adenosine and have solved the three-dimensional structure to atomic resolution by x-ray crystallography. This has allowed the direct visualization of intercalative binding by this drug to a fragment of a nucleic acid double helix.
Similar articles
-
Drug-nucleic acid interaction: X-ray crystallographic determination of an ethidium-dinucleoside monophosphate crystalline complex, ethidium: 5-iodouridylyl(3'-5')adenosine.Philos Trans R Soc Lond B Biol Sci. 1975 Nov 6;272(915):137-46. doi: 10.1098/rstb.1975.0076. Philos Trans R Soc Lond B Biol Sci. 1975. PMID: 1810
-
Visualization of drug-nucleic acid interactions at atomic resolution. I. Structure of an ethidium/dinucleoside monophosphate crystalline complex, ethidium:5-iodouridylyl (3'-5') adenosine.J Mol Biol. 1977 Aug 15;114(3):301-15. doi: 10.1016/0022-2836(77)90252-2. J Mol Biol. 1977. PMID: 909090 No abstract available.
-
Visualization of drug-nucleic acid interactions at atomic resolution. VII. Structure of an ethidium/dinucleoside monophosphate crystalline complex, ethidium: uridylyl(3'-5') adenosine.J Biomol Struct Dyn. 1984 Mar;1(5):1161-77. doi: 10.1080/07391102.1984.10507510. J Biomol Struct Dyn. 1984. PMID: 6400816
-
Visualization of drug-nucleic acid interactions at atomic resolution. II. Structure of an ethidium/dinucleoside monophosphate crystalline complex, ethidium:5-iodocytidylyl (3'-5') guanosine.J Mol Biol. 1977 Aug 15;114(3):317-31. doi: 10.1016/0022-2836(77)90253-4. J Mol Biol. 1977. PMID: 909091 No abstract available.
-
Structure and conformation of nucleosides and nucleotides and their analogs as determined by x-ray diffraction.Ann N Y Acad Sci. 1975 Aug 8;255:3-42. doi: 10.1111/j.1749-6632.1975.tb29211.x. Ann N Y Acad Sci. 1975. PMID: 1103684 Review. No abstract available.
Cited by
-
A mechanism for the entrapment of DNA at an air-water interface.Biophys J. 1977 Jun;18(3):275-88. doi: 10.1016/S0006-3495(77)85613-0. Biophys J. 1977. PMID: 890027 Free PMC article.
-
Ethidium bromide-(dC-dG-dC-dG)2 complex in solution: intercalation and sequence specificity of drug binding at the tetranucleotide duplex level.Proc Natl Acad Sci U S A. 1976 Oct;73(10):3343-7. doi: 10.1073/pnas.73.10.3343. Proc Natl Acad Sci U S A. 1976. PMID: 1068447 Free PMC article.
-
Modeling and Analysis of Intercalant Effects on Circular DNA Conformation.ACS Nano. 2016 Sep 27;10(9):8910-7. doi: 10.1021/acsnano.6b04876. Epub 2016 Aug 29. ACS Nano. 2016. PMID: 27559753 Free PMC article.
-
Premeltons in DNA.J Struct Funct Genomics. 2016 Mar;17(1):17-31. doi: 10.1007/s10969-016-9202-4. Epub 2016 Mar 16. J Struct Funct Genomics. 2016. PMID: 26984848 Free PMC article. Review.
-
A reexamination of the problem of resonance energy transfer between DNA intercalated chromophores using bisintercalating compounds.Nucleic Acids Res. 1977;4(5):1361-79. doi: 10.1093/nar/4.5.1361. Nucleic Acids Res. 1977. PMID: 896464 Free PMC article.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
