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. 1975 Feb;72(2):628-32.
doi: 10.1073/pnas.72.2.628.

X-ray crystallographic visualization of drug-nucleic acid intercalative binding: structure of an ethidium-dinucleoside monophosphate crystalline complex, Ethidium: 5-iodouridylyl (3'-5') adenosine

C C Tsai, S C Jain, H M Sobell

X-ray crystallographic visualization of drug-nucleic acid intercalative binding: structure of an ethidium-dinucleoside monophosphate crystalline complex, Ethidium: 5-iodouridylyl (3'-5') adenosine

C C Tsai et al. Proc Natl Acad Sci U S A. 1975 Feb.

Abstract

We have cocrystallized the drug ethidium bromide with the dinucleoside monophosphate 5-iodouridylyl(3'-5')adenosine and have solved the three-dimensional structure to atomic resolution by x-ray crystallography. This has allowed the direct visualization of intercalative binding by this drug to a fragment of a nucleic acid double helix.

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References

    1. Proc Natl Acad Sci U S A. 1960 Jan;46(1):57-64 - PubMed
    1. Adv Chemother. 1964;25:35-83 - PubMed
    1. Biochim Biophys Acta. 1964 Jun 22;87:358-61 - PubMed
    1. Proc Natl Acad Sci U S A. 1963 Jan 15;49:94-102 - PubMed
    1. J Mol Biol. 1961 Feb;3:18-30 - PubMed

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