doi: 10.1073/pnas.72.4.1281.
Isolation and characterization of vitamin K-dependent region of bovine blood clotting factor X
- PMID: 1055402
- PMCID: PMC432516
- DOI: 10.1073/pnas.72.4.1281
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Isolation and characterization of vitamin K-dependent region of bovine blood clotting factor X
Proc Natl Acad Sci U S A.
1975 Apr.
Abstract
A 39-residue peptide from the tryptic digestion of bovine blood clotting factor X has been isolated by specific adsorption on barium citrate. The amino- and carboxyl-terminal sequences of the peptide were determined and compared to the vitamin K-dependent Ca2+-binding region from bovine prothrombin. The factor X peptide was found to contain gamma-carboxyglutamic acid residues, and the results of independent analysis are consistent with all 14 glutamic acid residues as gamma-carboxyglutamic acid. The similarity of the factor X peptide to the prothrombin peptide supports the hypothesis that the vitamin K-dependent blood clotting proteins are descended from a common ancestral gene.
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