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. 1975 Apr;72(4):1281-5.
doi: 10.1073/pnas.72.4.1281.

Isolation and characterization of vitamin K-dependent region of bovine blood clotting factor X

J B Howard, G L Nelsestuen

Isolation and characterization of vitamin K-dependent region of bovine blood clotting factor X

J B Howard et al. Proc Natl Acad Sci U S A. 1975 Apr.

Abstract

A 39-residue peptide from the tryptic digestion of bovine blood clotting factor X has been isolated by specific adsorption on barium citrate. The amino- and carboxyl-terminal sequences of the peptide were determined and compared to the vitamin K-dependent Ca2+-binding region from bovine prothrombin. The factor X peptide was found to contain gamma-carboxyglutamic acid residues, and the results of independent analysis are consistent with all 14 glutamic acid residues as gamma-carboxyglutamic acid. The similarity of the factor X peptide to the prothrombin peptide supports the hypothesis that the vitamin K-dependent blood clotting proteins are descended from a common ancestral gene.

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References

    1. Thromb Diath Haemorrh. 1967 Aug 15;18(1-2):211-22 - PubMed
    1. Biochemistry. 1964 Nov;3:1720-5 - PubMed
    1. Biochim Biophys Acta. 1964 Aug 19;90:436-9 - PubMed
    1. Thromb Diath Haemorrh. 1958 May 1;2(1-2):24-38 - PubMed
    1. Proc Natl Acad Sci U S A. 1974 Jul;71(7):2730-3 - PubMed

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