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. 1975 Apr;72(4):1523-7.
doi: 10.1073/pnas.72.4.1523.

Two classes of translational control RNA: their role in the regulation of protein synthesis

A J Bester, D S Kennedy, S M Heywood

Two classes of translational control RNA: their role in the regulation of protein synthesis

A J Bester et al. Proc Natl Acad Sci U S A. 1975 Apr.

Abstract

Two classes of translation control RNA (tcRNA) have been isolated from embryonic chick muscle. One of these classes, the tcRNA isolated from messenger ribonucleoprotein particles (mRNP-tcRNA), is effective in inhibiting the translation of mRNP-mRNA while having little if any effect on polysomal mRNA. The other class, polysome-tcRNA, has no effect on mRNP-mRNA while it stimulates the translation of polysomal mRNA. The mRNP tcRNA contains approximately 50 percent uridylate residues and forms small but stable hybrids with poly (A), while polysome-tcRNA contains fewer uridylate residues and is much less effective in forming a hybrid with poly (A). A proposed model concerning the role of these two classes of tcRNA in the regulation of protein synthesis is presented.

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References

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