doi: 10.1016/s0014-827x(99)00068-3.
Synthesis and anti-inflammatory activities of some thiazolo[3,2-a]pyrimidine derivatives
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- PMID: 10555260
- DOI: 10.1016/s0014-827x(99)00068-3
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Synthesis and anti-inflammatory activities of some thiazolo[3,2-a]pyrimidine derivatives
Farmaco.
.
Abstract
Sixteen new 2-benzylidene-7-methyl-3-oxo-5-(substituted phenyl)-2, 3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid methyl esters (1a-4d) have been synthesized by reacting 1,2,3,4-tetrahydropyrimidine-2-thiones (1-4) with chloroacetic acid and appropriate benzaldehydes in a single step. Their structures have been proved by IR, 1H NMR, mass spectra and elemental analysis. The compounds were tested for their anti-inflammatory activities. Test results revealed that compounds 1b, 1c, 4a and 4c exerted moderate anti-inflammatory activity at the 100 mg/kg dose level compared with indomethacin.
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