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. 1999 Nov 2;38(21):3186-3189.

Facile, Novel Methodology for the Synthesis of Spiro

PB Alper  1 , C Meyers, A Lerchner, DR Siegel, EM Carreira
Affiliations
  • PMID: 10556897

Facile, Novel Methodology for the Synthesis of Spiro

PB Alper et al. Angew Chem Int Ed Engl. .

Abstract

The role of the bifunctional catalyst is decisive: The magnesium ion as Lewis acid and its nucleophilic iodide counterion contribute in synergy to the successful ring expansion of the cyclopropane 1 by aldimine 2 [Eq. (1)]. This reaction offers a novel route to spiro[pyrrolidin-3,3'-oxindoles] 3.

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