doi: 10.1126/science.286.5443.1381.
Class II-independent generation of CD4 memory T cells from effectors
Affiliations
- PMID: 10558997
- DOI: 10.1126/science.286.5443.1381
Item in Clipboard
Class II-independent generation of CD4 memory T cells from effectors
Science.
.
Abstract
The factors required for the generation of memory CD4 T cells remain unclear, and whether there is a continuing requirement for antigen stimulation is critical to design of vaccine strategies. CD4 effectors generated in vitro from naïve CD4 T cells of mice efficiently gave rise to small resting memory cells after transfer to class II-deficient hosts, indicating no requirement for further antigen or class II recognition.
Comment in
-
Memory T cells don't need practice.Science. 1999 Nov 12;286(5443):1267-8. doi: 10.1126/science.286.5443.1267a. Science. 1999. PMID: 10610529 No abstract available.
Similar articles
-
Withdrawal of stimulation may initiate the transition of effector to memory CD4 cells.J Immunol. 2002 Feb 1;168(3):1095-102. doi: 10.4049/jimmunol.168.3.1095. J Immunol. 2002. PMID: 11801643
-
Generation and in vivo persistence of polarized Th1 and Th2 memory cells.Immunity. 1994 Oct;1(7):543-52. doi: 10.1016/1074-7613(94)90044-2. Immunity. 1994. PMID: 7600283
-
C-C chemokine receptor 4 expression defines a major subset of circulating nonintestinal memory T cells of both Th1 and Th2 potential.J Immunol. 2001 Jan 1;166(1):103-11. doi: 10.4049/jimmunol.166.1.103. J Immunol. 2001. PMID: 11123282
-
Linear "2-0-1" lymphocyte development: hypotheses on cellular bases for immunity.Trends Immunol. 2003 May;24(5):235-41. doi: 10.1016/s1471-4906(03)00080-2. Trends Immunol. 2003. PMID: 12738416 Review. No abstract available.
-
CD4 T-cell memory can persist in the absence of class II.Philos Trans R Soc Lond B Biol Sci. 2000 Mar 29;355(1395):407-11. doi: 10.1098/rstb.2000.0581. Philos Trans R Soc Lond B Biol Sci. 2000. PMID: 10794062 Free PMC article. Review.
Cited by
-
IL-7-Induced Glycerol Transport and TAG Synthesis Promotes Memory CD8+ T Cell Longevity.Cell. 2015 May 7;161(4):750-61. doi: 10.1016/j.cell.2015.03.021. Cell. 2015. PMID: 25957683 Free PMC article.
-
T cell-independent interleukin 15Ralpha signals are required for bystander proliferation.J Exp Med. 2001 Oct 15;194(8):1187-94. doi: 10.1084/jem.194.8.1187. J Exp Med. 2001. PMID: 11602647 Free PMC article.
-
Eradication of HIV and Cure of AIDS, Now and How?Front Immunol. 2013 Oct 18;4:337. doi: 10.3389/fimmu.2013.00337. Front Immunol. 2013. PMID: 24151495 Free PMC article. Review.
-
Intranasal DNA Vaccine for Protection against Respiratory Infectious Diseases: The Delivery Perspectives.Pharmaceutics. 2014 Jul 10;6(3):378-415. doi: 10.3390/pharmaceutics6030378. Pharmaceutics. 2014. PMID: 25014738 Free PMC article.
-
Persistence and function of central and effector memory CD4+ T cells following infection with a gastrointestinal helminth.J Immunol. 2006 Jul 1;177(1):511-8. doi: 10.4049/jimmunol.177.1.511. J Immunol. 2006. PMID: 16785548 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
