Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1999 Nov 12;286(5443):1381-3.
doi: 10.1126/science.286.5443.1381.

Class II-independent generation of CD4 memory T cells from effectors

S L Swain  1 , H Hu, G Huston
Affiliations

Class II-independent generation of CD4 memory T cells from effectors

S L Swain et al. Science. .

Abstract

The factors required for the generation of memory CD4 T cells remain unclear, and whether there is a continuing requirement for antigen stimulation is critical to design of vaccine strategies. CD4 effectors generated in vitro from naïve CD4 T cells of mice efficiently gave rise to small resting memory cells after transfer to class II-deficient hosts, indicating no requirement for further antigen or class II recognition.

PubMed Disclaimer

Comment in

  • Memory T cells don't need practice.
    Hagmann M. Hagmann M. Science. 1999 Nov 12;286(5443):1267-8. doi: 10.1126/science.286.5443.1267a. Science. 1999. PMID: 10610529 No abstract available.

Substances

LinkOut - more resources