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. 1975 Jun;72(6):2091-4.
doi: 10.1073/pnas.72.6.2091.

Lymphokine-induced production and release of lysosomal enzymes by macrophages

R M Pantalone, R C Page

Lymphokine-induced production and release of lysosomal enzymes by macrophages

R M Pantalone et al. Proc Natl Acad Sci U S A. 1975 Jun.

Abstract

MACROPHAGES ARE ASSOCIATED WITH MOST CHRONIC INFLAMMATORY LESIONS, AND THESE CELLS CONTAIN ENZYMES THAT ARE ABLE TO DESTROY CONNECTIVE TISSUE CONSTITUENTS. Normal lymphoid cells responding to a mitogen, phytohemagglutinin-P, release factor(s) that cause a marked increase in the size and enzyme content for mononuclear phagocytes maintained in culture. The stimulated macrophages, which by several criteria remain otherwise viable and healthy, selectively release large quantities of hydrolytic enzymes to the culture medium.

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References

    1. Proc Natl Acad Sci U S A. 1974 Sep;71(9):3598-601 - PubMed
    1. J Reticuloendothel Soc. 1974 May;15(5):413-38 - PubMed
    1. J Immunol. 1973 Oct;111(4):992-5 - PubMed
    1. J Exp Med. 1973 Oct 1;138(4):952-64 - PubMed
    1. Clin Exp Immunol. 1973 Jul;14(3):371-6 - PubMed

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