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Review
. 1999 Nov;104(10):1337-9.
doi: 10.1172/JCI8731.

Interleukin-18, rheumatoid arthritis, and tissue destruction

Affiliations
Review

Interleukin-18, rheumatoid arthritis, and tissue destruction

J M Dayer. J Clin Invest. 1999 Nov.
No abstract available

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Figures

Figure 1
Figure 1
Potential roles for IL-18 in various pathological conditions. Yellow highlighting indicates a potentially beneficial effect of IL-18.

Comment on

  • A proinflammatory role for IL-18 in rheumatoid arthritis.
    Gracie JA, Forsey RJ, Chan WL, Gilmour A, Leung BP, Greer MR, Kennedy K, Carter R, Wei XQ, Xu D, Field M, Foulis A, Liew FY, McInnes IB. Gracie JA, et al. J Clin Invest. 1999 Nov;104(10):1393-401. doi: 10.1172/JCI7317. J Clin Invest. 1999. PMID: 10562301 Free PMC article.

References

    1. Gracie JA, et al. A proinflammatory role for IL-18 in rheumatoid arthritis. J Clin Invest. 1999;104:1393–1401. - PMC - PubMed
    1. Okamura H, Tsutsui H, Kashiwamura S-I, Yoshimoto T, Nakanishi K. Interleukin-18: a novel cytokine that augments both innate and acquired immunity. Adv Immunol. 1998;70:281–312. - PubMed
    1. Dinarello CA, et al. Overview of interleukin-18: more than an interferon-γ inducing factor. J Leukoc Biol. 1998;63:658–664. - PubMed
    1. Gillespie MT, Horwood NJ. Interleukin-18: perspectives on the newest interleukin. Cytokine Growth Factor Rev. 1998;9:109–116. - PubMed
    1. Parnet P, Garka KE, Bonnert TP, Dower SK, Sims JE. IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP. J Biol Chem. 1996;271:3967–3970. - PubMed