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Review

. 1999 Nov;104(10):1341-2.

doi: 10.1172/JCI8732.

PACAP upsets stomach theory

S A Wank¹

Affiliations

Affiliation

¹ Digestive Diseases Branch, National Institute of Diabetes, Kidney and Digestive Diseases, National Institutes of Health, Building 10, Room 9C-103, 9000 Rockville Pike, Bethesda, Maryland 20892-1804, USA. stevew@bdg10.niddk.nih.gov

PMID: 10562295
PMCID: PMC409853
DOI: 10.1172/JCI8732

Review

PACAP upsets stomach theory

S A Wank. J Clin Invest. 1999 Nov.

. 1999 Nov;104(10):1341-2.

doi: 10.1172/JCI8732.

Author

S A Wank¹

Affiliation

¹ Digestive Diseases Branch, National Institute of Diabetes, Kidney and Digestive Diseases, National Institutes of Health, Building 10, Room 9C-103, 9000 Rockville Pike, Bethesda, Maryland 20892-1804, USA. stevew@bdg10.niddk.nih.gov

PMID: 10562295
PMCID: PMC409853
DOI: 10.1172/JCI8732

Erratum in

J Clin Invest 1999 Dec;104(12):1772

No abstract available

PubMed Disclaimer

Figures

Figure 1
Cephalic (neural) and peripheral (gastric and intestinal) endocrine and paracrine regulation of gastric acid secretion. G, G cell; P, parietal cell; D, D cell; M cell, mucus cell; ENS, enteric nervous system; GRP, gastrin-releasing peptide; GRPR, GRP receptor; SMS, somatostatin; VIP, vasoactive intestinal polypeptide; M, muscarinic receptor; M_3, muscarinic receptor type 3; SST2, somatostatin type 2 receptor; CCKA and CCKB, cholecystokinin type A and B receptors; Y₁, PYY type 1 receptor; PYY, peptide YY; H2, histamine type 2 receptor; Gal1, galanin type 1 receptor. Green lines indicate stimulation; red lines indicate inhibition.

See this image and copyright information in PMC

Comment on

PACAP type I receptor activation regulates ECL cells and gastric acid secretion.
Zeng N, Athmann C, Kang T, Lyu RM, Walsh JH, Ohning GV, Sachs G, Pisegna JR. Zeng N, et al. J Clin Invest. 1999 Nov;104(10):1383-91. doi: 10.1172/JCI7537. J Clin Invest. 1999. PMID: 10562300 Free PMC article.

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References

1. Malfertheiner P. Current concepts in dyspepsia: a world perspective. Eur J Gastroenterol Hepatol. 1999;11(Suppl. 1):25–29. - PubMed
1. Baron JH. The discovery of gastric acid. Gastroenterology. 1979;76:1056–1064. - PubMed
1. Soll AH. The actions of secretagogues on oxygen uptake by isolated mammalian parietal cells. J Clin Invest. 1978;61:370–380. - PMC - PubMed
1. Walsh, J.H. 1994. Gastrointestinal hormones. In: Physiology of the gastrointestinal tract. L.R. Johnson, editor. Raven Press. New York, NY. 1–129.
1. Yanagisawa K, Yang H, Walsh JH, Tache Y. Role of acetylcholine, histamine and gastrin in the acid response to intracisternal injection of TRH analog, RX 77368, in the rat. Regul Pept. 1990;27:161–170. - PubMed

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