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. 1979 Mar;136(3):311-3.
doi: 10.1176/ajp.136.3.311.

Phenylethylamine in rhesus monkeys: interactions with alpha-methyl-para-tyrosine and l-dopa

J R Tinklenberg, J C Gillin, G M Murphy Jr, R Staub, R J Wyatt

Phenylethylamine in rhesus monkeys: interactions with alpha-methyl-para-tyrosine and l-dopa

J R Tinklenberg et al. Am J Psychiatry. 1979 Mar.

Abstract

Rhesus monkeys, pretreated with alpha-methyl-para-tryosine (AMPT) and subsequently injected with phenylethylamine (PEA), did not demonstrate the characteristic amphetamine-like PEA effects. However, when AMPT pretreatment was followed with l-dopa and then PEA injection, PEA effects were restored. These results are compatible with a dopamine theory of schizophrenia.

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