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Clinical Trial
. 1999 Dec;41(6):1002-7.
doi: 10.1016/s0190-9622(99)70261-6.

Therapeutic response of basal cell carcinoma to the immune response modifier imiquimod 5% cream

K R Beutner  1 , J K Geisse, D Helman, T L Fox, A Ginkel, M L Owens
Affiliations
Clinical Trial

Therapeutic response of basal cell carcinoma to the immune response modifier imiquimod 5% cream

K R Beutner et al. J Am Acad Dermatol. 1999 Dec.

Abstract

Background: Basal cell carcinoma (BCC) responds to interferon therapy. Imiquimod is a cytokine and interferon inducer.

Objective: This randomized, double-blind pilot trial evaluated the safety and efficacy of imiquimod 5% cream versus vehicle in the treatment of BCC.

Methods: In this population of 35 patients with BCC, 24 received imiquimod 5% cream and 11 received vehicle cream in 1 of 5 dosing regimens for up to 16 weeks. Six weeks after treatment, an excisional biopsy of the target site was performed.

Results: BCC cleared (on the basis of histologic examination) in all 15 patients (100%) dosed twice daily, once daily, and 3 times weekly; in 3 of 5 (60%) patients dosed twice weekly; 2 of 4 (50%) dosed once weekly; and in 1 of 11 (9%) treated with vehicle. Adverse events were predominantly local reactions at the target tumor site, with the incidence and severity of local skin reactions declining in groups dosed less frequently.

Conclusion: Imiquimod 5% cream shows clinical efficacy in the treatment of BCC.

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