Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1999 Nov;14(11):699-704.
doi: 10.1046/j.1525-1497.1999.11188.x.

Preventive care in chronic liver disease

T R Riley  1 , J P Smith
Affiliations
Review

Preventive care in chronic liver disease

T R Riley et al. J Gen Intern Med. 1999 Nov.

Abstract

Objective: To identify preventive care measures that are appropriate for and specific to patients with chronic liver disease and to provide recommendations and information that can be shared with patients.

Measurements: A review of the literature was undertaken using MEDLINE from 1970 to present. Priority was given to randomized controlled studies, but case reports, case-control studies, and reviews were included.

Main results: Evidence for the avoidance of alcohol and other toxic substances, immunizations, and dietary modifications for chronic liver disease is summarized. In addition, measures that are effective in the mitigation of the complications of cirrhosis are reviewed.

Conclusions: Preventive care can play an important role in patients with chronic liver diseases. Based on the existing data, the preventive strategies of alcohol avoidance, hepatitis vaccination, avoidance of NSAIDs nonsteroidal anti-inflammatory drugs, iron supplementation when appropriate, and a low-fat diet are prudent in patients with chronic liver disease. Once cirrhosis develops, screening for hepatocellular cancer with alpha-fetoprotein testing and ultrasound, and screening for varices by endoscopy are justified.

PubMed Disclaimer

Comment in

  • Chronic liver disease.
    Gordon SG. Gordon SG. J Gen Intern Med. 2000 Feb;15(2):142. doi: 10.1046/j.1525-1497.2000.11050a.x. J Gen Intern Med. 2000. PMID: 10722329 Free PMC article. No abstract available.
  • Preventative care in chronic liver diseases.
    O'Rorke JE, O'Keefe M. O'Rorke JE, et al. J Gen Intern Med. 2000 Apr;15(4):273-4. doi: 10.1111/j.1525-1497.2000.01006_3.x. J Gen Intern Med. 2000. PMID: 10841669 Free PMC article. No abstract available.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Alter JM, Margolis HS, Krawczynski K. The natural history of community-acquired hepatitis C in the United States. N Engl J Med. 1992;327:1899–905. - PubMed
    1. Zein NN, Rakela J, Krawitt EL. Hepatitis C virus genotypes in the United States: epidemiology, pathogenicity, and response to interferon therapy. Ann Intern Med. 1996;125:634–9. - PubMed
    1. Poupon RE, Balkau B, Eschwege E. A multicenter, controlled trial of ursodial for the treatment of primary biliary cirrhosis. N Engl J Med. 1991;324:1548–54. - PubMed
    1. Propst A, Propst T, Zangerl G. Prognosis and life expectancy in chronic liver disease. Dig Dis Sci. 1995;40:1805–15. - PubMed
    1. Thun MJ, Peto R, Lopez AD. Alcohol consumption and mortality among middle-aged and elderly U.S. adults. N Engl J Med. 1997;337:1705–14. - PubMed

MeSH terms