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. 1975 May;72(5):1895-8.
doi: 10.1073/pnas.72.5.1895.

Secretion of a nerve growth factor by mouse neuroblastoma cells in culture

R A Murphy, N J Pantazis, B G Arnason, M Young

Secretion of a nerve growth factor by mouse neuroblastoma cells in culture

R A Murphy et al. Proc Natl Acad Sci U S A. 1975 May.

Abstract

Analyses of supernatant solutions from mouse C1300 neuroblastoma cultures by two independent immunoassays reveal that these cells secrete a factor which is immunochemically similar to mouse submaxillary gland nerve growth factor. The neuroblastoma factor is also biologically active in inducing neurite outgrowth from embryonic sensory ganglia-an effect that is completely blocked by specific antibody to nerve growth factor. Neuroblastoma cells are known to be functionally responsive to nerve growth factor, and the observation that they secrete a molecule like it may mean that these cells require or utilize the factor during growth in culture.

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References

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