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. 1999 Sep;34(9):965-9.
doi: 10.1007/s11745-999-0446-9.

Effects of conjugated linoleic acid isomers on the hepatic microsomal desaturation activities in vitro

L Bretillon  1 , J M Chardigny, S Grégoire, O Berdeaux, J L Sébédio
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Effects of conjugated linoleic acid isomers on the hepatic microsomal desaturation activities in vitro

L Bretillon et al. Lipids. 1999 Sep.

Abstract

The influence of individual conjugated linoleic acid (CLA) isomers on the delta6 desaturation of linoleic and alpha-linolenic acids and on the delta9 desaturation of stearic acid was investigated in vitro, using rat liver microsomes. The delta6 desaturation of 18:2n-6 was decreased from 23 to 38% when the ratio of 9cis,11trans-18:2 to 18:2n-6 increased from 0.5 to 2. The compound 10trans,12cis-18:2 exhibited a similar effect only at the highest concentration. The delta6 desaturation of alpha-linolenic acid was slightly affected by the presence of CLA isomers. The sole isomer to induce an inhibitory effect on the delta9 desaturation of stearic acid was 10trans,12cis-18:2.

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