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. 1975:39 Pt 1:539-45.
doi: 10.1101/sqb.1974.039.01.066.

The mechanism of replication of adenovirus type 5 DNA

J S Sussenbach, D J Ellens, P C Van Der Vliet, M G Kuijk, P H Steenbergh, J M Vlak, T H Rozijn, H S Jansz

The mechanism of replication of adenovirus type 5 DNA

J S Sussenbach et al. Cold Spring Harb Symp Quant Biol. 1975.

Abstract

The analysis of replicating Ad5 DNA has led to a model for replication involving linear intermediates. The origin of replication has been localized at the molecular right end, suggesting the presence of a unique sequence of nucleotides which can be recognized by an initiation factor. On the other hand, the study of the molecular ends has shown, so far, a high degree of symmetry in the terminal nucleotide sequences of Ad5 DNA. A more detailed study of the nucleotide sequences at the ends is necessary to solve this problem.

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