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. 1999 Oct;65(7):604-9.
doi: 10.1055/s-1999-14032.

Antiviral and anticoagulant activities of a water-soluble fraction of the marine diatom Haslea ostrearia

J P Bergé  1 , N Bourgougnon, S Alban, F Pojer, S Billaudel, J C Chermann, J M Robert, G Franz
Affiliations

Antiviral and anticoagulant activities of a water-soluble fraction of the marine diatom Haslea ostrearia

J P Bergé et al. Planta Med. 1999 Oct.

Abstract

A water-soluble fraction from the marine diatom Haslea ostrearia was capable to inhibit the in vitro replication of HSV-1 in Vero cells with 50% inhibitory concentration (EC50) of 14 micrograms/ml at a multiplicity of infection of 0.01 ID50/cells. In addition, this fraction delayed the HIV-1-induced syncitia formation on MT4 cells. At concentrations up to 200 micrograms/ml, no cytotoxicity was observed for both the Vero and MT4 cells. The fraction only inhibited the blood coagulation process at concentrations considerably exceeding the EC50.

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