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. 1999 Oct;128(4):509-10.
doi: 10.1016/s0002-9394(99)00196-8.

Emerging ciprofloxacin-resistant Pseudomonas aeruginosa

N A Chaudhry  1 , H W Flynn Jr, T G Murray, H Tabandeh, M O Mello Jr, D Miller
Affiliations

Emerging ciprofloxacin-resistant Pseudomonas aeruginosa

N A Chaudhry et al. Am J Ophthalmol. 1999 Oct.

Abstract

Purpose: To report a clinical series of ciprofloxacin-resistant ocular isolates of Pseudomonas aeruginosa from a tertiary care ophthalmic center.

Methods: Review of in vitro sensitivities of all ocular isolates of P. aeruginosa be tween July 1991 and September 1998. In vitro resistance was defined as a minimum inhibitory concentration of 4 or more microg per ml.

Results: Nine of 423 ocular isolates of P. aeruginosa showed in vitro resistance to ciprofloxacin. From 1991 to 1994, 0.44% (1/227) of ocular isolates were resistant to ciprofloxacin, whereas from 1995 to 1998, 4.1% (8/ 196) of ocular isolates showed in vitro resistance (P = .014).

Conclusions: Ciprofloxacin-resistant P. aeruginosa has been identified in recent clinical ocular specimens. Ciprofloxacin resistance among ocular isolates of P. aeruginosa is a local and worldwide concern.

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