Urinary levels of tissue kallikrein in the South African Black and Indian hypertensives

Abstract

It is accepted that Black subjects differ from White and Indian hypertensives in their response to hypotensive agents. Black hypertensives in the USA have a lower urinary tissue kallikrein (TK) excretion levels compared to White hypertensives. It has been suggested that Black patients respond better to thiazide diuretics compared to beta-blockers because thiazides increase whereas beta-blockers decrease tissue kallikrein excretion. This study compares the excretion of urinary TK in Black and Indian hypertensive and normotensive subjects. Urinary TK levels were measured with the selective, synthetic peptic substrate with the sequence of H-D-Val-Leu-Arg-pNA. Ten hypertensive patients on placebo therapy and 10 normotensive Black and Indian subjects provided three samples at weeks 0, 2 and 4 for the determination of urinary TK. The results were analysed using analysis of variance to compare the two racial groups. There were no significant differences in urinary TK values of the three bi-weekly individual samples. Urinary tissue kallikrein values (ng TK/microg protein) in Indian hypertensives were in general lower than Black hypertensives.