Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1999 Nov 29;147(5):909-12.
doi: 10.1083/jcb.147.5.909.

Life without perlecan has its problems

B R Olsen  1
Affiliations
Review

Life without perlecan has its problems

B R Olsen. J Cell Biol. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Structure of perlecan (see Iozzo 1998). Several distinct protein modules are organized in five domains (I–V). Domain I contains the glycosaminoglycan side chains (indicated by wavy lines). Note that in domain IV only six of the 21 Ig-like repeats are shown.
See this image and copyright information in PMC

References

    1. Ahn J., Ludecke H.J., Lindow S., Horton W.A., Lee B., Wagner M.J., Horsthemke B., Wells D.E. Cloning of the putative tumour suppressor gene for hereditary multiple exostoses (EXT1) Nat. Genet. 1995;11:137–143. - PubMed
    1. Aviezer D., Hecht D., Safran M., Eisinger M., David G., Yayon A. Perlecan, basal lamina proteoglycan, promotes basic fibroblast growth factor-receptor binding, mitogenesis, and angiogenesis. Cell. 1994;79:1005–1013. - PubMed
    1. Bellaiche Y., The I., Perrimon N. Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion. Nature. 1998;394:85–88. - PubMed
    1. Costell M., Gustafsson E., Aszodi A., Morgelin M., Bloch W., Hunziker E., Addicks K., Timpl R., Fassler R. Perlecan maintains the integrity of cartilage and some basement membranes. J. Cell Biol. 1999;147:1109–1122. - PMC - PubMed
    1. Deng C., Wynshaw-Boris A., Zhou F., Kuo A., Leder P. Fibroblast growth factor receptor 3 is a negative regulator of bone growth. Cell. 1996;84:911–921. - PubMed

MeSH terms