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Review
. 1999 Dec 4;319(7223):1492-5.
doi: 10.1136/bmj.319.7223.1492.

Calculating the number needed to treat for trials where the outcome is time to an event

Affiliations
Review

Calculating the number needed to treat for trials where the outcome is time to an event

D G Altman et al. BMJ. .
No abstract available

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Figures

Figure 1
Figure 1
Kaplan-Meier plots of survival for 164 patients with non-small lung cancer treated with radiotherapy plus chemotherapy versus radiotherapy alone
Figure 2
Figure 2
Number needed to treat to either benefit or harm with 95% confidence interval by time since treatment for 164 patients with non-small cell lung cancer treated with radiotherapy plus chemotherapy versus radiotherapy alone9 on basis of Cox regression model including only treatment

References

    1. Cook RJ, Sackett DL. The number needed to treat: a clinically useful measure of treatment effect. BMJ. 1995;310:452–454. - PMC - PubMed
    1. Sackett DL, Richardson WS, Rosenberg W, Haynes RB. Evidence-based medicine. How to practice and teach EBM. London: Churchill Livingstone; 1997. pp. 136–141. , 168-70.
    1. Sackett DL, Haynes RB, Guyatt GH, Tugwell P. Clinical epidemiology: a basic science for clinical medicine, 2nd ed. Boston: Little Brown; 1991. p. 208.
    1. Altman DG, De Stavola BL, Love SB, Stepniewska KA. Review of survival analyses published in cancer journals. Br J Cancer. 1995;72:511–518. - PMC - PubMed
    1. Medical Research Council Rectal Cancer Working Party. Randomised trial of surgery alone versus radiotherapy followed by surgery for potentially operable locally advanced rectal cancer. Lancet. 1996;348:1605–1610. - PubMed

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