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Clinical Trial
. 1999 Oct;48(4):631-4.
doi: 10.1046/j.1365-2125.1999.00059.x.

Fenoterol stimulates human erythropoietin production via activation of the renin angiotensin system

S M Freudenthaler  1 , T Schenck, I Lucht, C H Gleiter
Affiliations
Clinical Trial

Fenoterol stimulates human erythropoietin production via activation of the renin angiotensin system

S M Freudenthaler et al. Br J Clin Pharmacol. 1999 Oct.

Abstract

Aims: The present study assessed the hypothesis that the beta2 sympathomimetic fenoterol influences the production of erythropoietin (EPO) by activation of the renin angiotensin system (RAS), i.e. angiotensin II.

Methods: In an open, parallel, randomized study healthy volunteers received i.v. either placebo (electrolyte solution), fenoterol or fenoterol in combination with an oral dose of the AT1-receptor antagonist losartan.

Results: Compared with placebo treatment AUCEPO(0,24 h) was significantly increased after fenoterol application by 48% whereas no increase in the group receiving fenoterol and losartan could be detected. The rise of PRA was statistically significant under fenoterol and fenoterol plus lorsartan.

Conclusions: Stimulation of EPO production during fenoterol infusion appears to be angiotensin II-mediated. Thus, angiotensin II may be considered as one important physiological modulator of EPO production in humans.

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Figures

Figure 1
Figure 1
Time course of erythropoietin serum concentrations expressed in percentage of baseline values (mean±s.e.mean; *P < 0.05 vs placebo) where • is placebo, ▵ is fenoterol and □ is fenoterol+losartan.
See this image and copyright information in PMC

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References

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