doi: 10.1271/bbb.63.1823.
Transcriptional regulation of tyrosine phenol-lyase gene mediated through TyrR and cAMP receptor protein
Affiliations
- PMID: 10586511
- DOI: 10.1271/bbb.63.1823
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Transcriptional regulation of tyrosine phenol-lyase gene mediated through TyrR and cAMP receptor protein
Biosci Biotechnol Biochem.
1999 Oct.
Free article
Abstract
Using a lac reporter system in Escherichia coli, we showed that the expression of E. herbicola tpl was regulated through TyrR and cAMP receptor protein. Three TyrR boxes upstream of tpl were essential for full expression. The results suggested that the tyrosine-mediated TyrR hexamerization was an important process. The DNA bending between two TyrR boxes, which is triggered by the binding of cAMP receptor protein, may facilitate the conformational change of TyrRs.
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