Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 1999 Dec;104(11):1483-4.
doi: 10.1172/JCI8825.

Single allele mutations at the heart of congenital disease

Comment

Single allele mutations at the heart of congenital disease

N Rosenthal et al. J Clin Invest. 1999 Dec.
No abstract available

PubMed Disclaimer

Comment on

References

    1. Harvey RP. NK-2 homeobox genes and heart development. Dev Biol. 1996;178:203–216. - PubMed
    1. Fu Y, Yan W, Mohun TJ, Evans SM. Vertebrate tinman homologues XNkx2-3 and XNkx2-5 are required for heart formation in a functionally redundant manner. Development. 1998;125:4439–4449. - PubMed
    1. Grow MW, Krieg PA. Tinman function is essential for vertebrate heart development: elimination of cardiac differentiation by dominant inhibitory mutants of the tinman-related genes, XNkx2-3 and XNkx2-5. Dev Biol. 1998;204:187–196. - PubMed
    1. Benson DW, et al. Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways. J Clin Invest. 1999;104:1567–1573. - PMC - PubMed
    1. Schott J-J, et al. Congential heart disease caused by mutations in the transcription factor NKX2-5. Science. 1998;281:108–111. - PubMed