Single allele mutations at the heart of congenital disease
- PMID: 10587507
- PMCID: PMC409868
- DOI: 10.1172/JCI8825
Single allele mutations at the heart of congenital disease
Comment on
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Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways.J Clin Invest. 1999 Dec;104(11):1567-73. doi: 10.1172/JCI8154. J Clin Invest. 1999. PMID: 10587520 Free PMC article.
References
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- Fu Y, Yan W, Mohun TJ, Evans SM. Vertebrate tinman homologues XNkx2-3 and XNkx2-5 are required for heart formation in a functionally redundant manner. Development. 1998;125:4439–4449. - PubMed
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- Grow MW, Krieg PA. Tinman function is essential for vertebrate heart development: elimination of cardiac differentiation by dominant inhibitory mutants of the tinman-related genes, XNkx2-3 and XNkx2-5. Dev Biol. 1998;204:187–196. - PubMed
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- Schott J-J, et al. Congential heart disease caused by mutations in the transcription factor NKX2-5. Science. 1998;281:108–111. - PubMed
