Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1999 Dec;156(12):1986-8.
doi: 10.1176/ajp.156.12.1986.

Rostral and orbital prefrontal cortex dysfunction in the manic state of bipolar disorder

H P Blumberg  1 , E Stern, S Ricketts, D Martinez, J de Asis, T White, J Epstein, N Isenberg, P A McBride, I Kemperman, S Emmerich, V Dhawan, D Eidelberg, J H Kocsis, D A Silbersweig
Affiliations

Rostral and orbital prefrontal cortex dysfunction in the manic state of bipolar disorder

H P Blumberg et al. Am J Psychiatry. 1999 Dec.

Abstract

Objective: This study investigated prefrontal cortex function in the manic state of bipolar disorder.

Method: High-sensitivity [15O]H2O positron emission tomography and a word generation activation paradigm were used to study regional cerebral blood flow in five manic and six euthymic individuals with bipolar disorder and in five healthy individuals.

Results: Decreased right rostral and orbital prefrontal cortex activation during word generation and decreased orbitofrontal activity during rest were associated with mania.

Conclusions: The data support the presence of rostral and orbital prefrontal dysfunction in primary mania. These findings, when seen in the context of the human brain lesion and the behavioral neuroanatomic literatures, may help to explain some of the neurobehavioral abnormalities characteristic of the manic state.

PubMed Disclaimer

Publication types