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Comment
. 1999 Dec 7;96(25):14191-2.
doi: 10.1073/pnas.96.25.14191.

ADD-1 provides major new insight into the mechanism of insulin action

J S Flier, A N Hollenberg
Comment

ADD-1 provides major new insight into the mechanism of insulin action

J S Flier et al. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Figure 1
Figure 1
A scheme for the role of ADD-1/SREBP-1c in insulin action. Insulin signaling through insulin receptors on responsive cells induces, by an as yet uncertain pathway, increased transcription of the ADD-1/SREBP-1c gene. Insulin also may affect this protein by phosphorylation and by altering processing. ADD-1/SREBP-1c then acts on promoters in insulin target genes to increase (and possibly decrease in other cases) gene expression. ADD-1/SREBP-1c also may influence insulin action by affecting the function and/or expression of peroxisome proliferator-activated receptor-γ (PPARγ), which may then also influence insulin action.
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References

    1. Virkamaki A, Ueki K, Kahn C R. J Clin Invest. 1999;103:931–943. - PMC - PubMed
    1. O'Brien R M, Granner D K. Physiol Rev. 1996;76:1109–1161. - PubMed
    1. Foretz M, Guichard C, Ferré P, Foufelle F. Proc Natl Acad Sci USA. 1999;96:12737–12742. - PMC - PubMed
    1. Shimomura I, Bashmakov Y, Ikemoto S, Horton J D, Brown M S, Goldstein J L. Proc Natl Acad Sci USA. 1999;96:13656–13661. - PMC - PubMed
    1. Tontonoz P, Kim J B, Graves R A, Spiegelman B M. Mol Cell Biol. 1993;13:4753–4759. - PMC - PubMed

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