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Clinical Trial
. 1999 Nov-Dec;17(6 Suppl 18):S66-8.

Methotrexate and leflunomide combination therapy for patients with active rheumatoid arthritis

P J Mroczkowski  1 , M E Weinblatt, J M Kremer
Affiliations
  • PMID: 10589360
Clinical Trial

Methotrexate and leflunomide combination therapy for patients with active rheumatoid arthritis

P J Mroczkowski et al. Clin Exp Rheumatol. 1999 Nov-Dec.

Abstract

An open-label, one-year study was conducted to evaluate the safety and clinical response to leflunomide and methotrexate combination therapy for rheumatoid arthritis. Study results revealed tolerable safety, no significant pharmacokinetic interactions between methotrexate and leflunomide, and suggested improved clinical response with combination therapy.

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