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. 2000 Jan;23(1):106-11.
doi: 10.1002/(sici)1097-4598(200001)23:1<106::aid-mus14>3.0.co;2-d.

Delay of muscle degeneration and necrosis in mdx mice by calpain inhibition

M A Badalamente  1 , A Stracher
Affiliations

Delay of muscle degeneration and necrosis in mdx mice by calpain inhibition

M A Badalamente et al. Muscle Nerve. 2000 Jan.

Abstract

Inhibition of muscle degeneration by the tripeptide calpain inhibitor, leupeptin, was tested in vivo in a dystrophin-deficient mdx murine model. In a short-term control study, intramuscular administration of leupeptin for 30 days inhibited muscle degeneration as assessed by histologic analysis. Calpain inhibition could be correlated with retention of myofiber size and our results suggest that this may be a promising treatment modality in human Duchenne muscular dystrophy.

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