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. 1975 Aug;72(8):2930-4.
doi: 10.1073/pnas.72.8.2930.

Synthesis of RNA containing a methylated blocked 5' terminus by HeLa nuclear homogenates

Y Groner, J Hurwitz

Synthesis of RNA containing a methylated blocked 5' terminus by HeLa nuclear homogenates

Y Groner et al. Proc Natl Acad Sci U S A. 1975 Aug.

Abstract

RNA synthesized in vitro by HeLa nuclei contains a variety of blocked methylated 5'-terminal structures that can be grouped into four general types: (a) m(7)GppN(m)p...; (b) m(7)GppN(m)pM(m)p...; (c) m(7)GpppN(m)p...; and (d) m(7)GpppN(m)pM(m).... Both N(m) and M(m) can be either one of the four 2'-O-methylated nucleosides. The relative amounts of the N(m) species are G = 45%, A = 25%, U = 20%, and C = 10%.

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References

    1. Proc Natl Acad Sci U S A. 1974 Aug;71(8):3045-9 - PubMed
    1. J Biol Chem. 1974 Oct 25;249(20):6486-94 - PubMed
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