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. 2000 Jan 1;28(1):311-5.
doi: 10.1093/nar/28.1.311.

COMPEL: a database on composite regulatory elements providing combinatorial transcriptional regulation

O V Kel-Margoulis  1 , A G Romashchenko, N A Kolchanov, E Wingender, A E Kel
Affiliations

COMPEL: a database on composite regulatory elements providing combinatorial transcriptional regulation

O V Kel-Margoulis et al. Nucleic Acids Res. .

Abstract

COMPEL is a database on composite regulatory elements, the basic structures of combinatorial regulation. Composite regulatory elements contain two closely situated binding sites for distinct transcription factors and represent minimal functional units providing combinatorial transcriptional regulation. Both specific factor-DNA and factor-factor interactions contribute to the function of composite elements (CEs). Information about the structure of known CEs and specific gene regulation achieved through such CEs appears to be extremely useful for promoter prediction, for gene function prediction and for applied gene engineering as well. The structure of the relational model of COMPEL is determined by the concept of molecular structure and regulatory role of CEs. Based on the set of a particular CE, a program has been developed for searching potential CEs in gene regulatory regions. WWW search and browse routines were developed for COMPEL release 3.0. The COMPEL database equipped with the search and browse tools is available at http://compel.bionet.nsc.ru/. The program for prediction of potential CEs of NFAT type is available at http://compel.bionet.nsc. ru/FunSite.html and http://transfac.gbf.de/dbsearch/funsitep/ s_comp.html

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Figures

Figure 1
Figure 1
Example entries of the COMPEL database. An entry of the table Composite Elements is shown in the blue rectangle, an Interactions entry in the yellow box and a References record in the green box. Green cylinders symbolize external databases.
See this image and copyright information in PMC

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References

    1. Perier R.C., Junier,Th., Bonnard,C. and Bucher,P. (1999) Nucleic Acids Res., 27, 307–309. Updated article in this issue: Nucleic Acids Res. (2000), 28, 302–303. - PMC - PubMed
    1. Heinemeyer T., Chen,X., Karas,H., Kel,A.E., Kel,O.V., Liebich,I., Meinhardt,T., Reuter,I., Schacherer,F. and Wingender,E. (1999) Nucleic Acids Res., 27, 318–322. Updated article in this issue: Nucleic Acids Res. (2000), 28, 316–319. - PMC - PubMed
    1. Kel A.E., Kolchanov,N.A., Kel,O.V., Romashencko,A.G., Ananko,E.A., Ignatieva,E.V., Merkulova,T.I., Podkolodnaya,O.A., Stepanenko,I.L., Kochetov,A.V., Kolpakov,F.A., Podkolodnyi,N.L. and Naumochkin,A.N. (1997) Mol. Biol. (Mosk)., 31, 626–636. - PubMed
    1. Kolchanov N.A., Ananko,E.A., Podkolodnaya,O.A., Ignatieva,E.V., Stepanenko,I.L., Kel-Margoulis,O.V., Kel,A.E., Merkulova,T.I., Goryachkovskaya,T.N., Busigina,T.N., Kolpakov,F.A., Podkolodny,N.L., Naumochkin,A.N. and Romashchenko,A.G. (1999) Nucleic Acids Res., 27, 303–306. Updated article in this issue: Nucleic Acids Res. (2000), 28, 298–301. - PMC - PubMed
    1. Kel O.V., Romaschenko,A.G., Kel,A.E., Naumochkin,A.N. and Kolchanov,N.A. (1995) Proceedings of the 28th Annual Hawaii International Conference on System Scienses [HICSS]. Biotechnology Computing, IEE Computer Society Press, Los Alamitos, CA, Vol. 5, pp. 42–51.

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