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. 2000 Jan 1;28(1):346-8.
doi: 10.1093/nar/28.1.346.

Human immunodeficiency virus reverse transcriptase and protease sequence database

R W Shafer  1 , D R Jung, B J Betts, Y Xi, M J Gonzales
Affiliations

Human immunodeficiency virus reverse transcriptase and protease sequence database

R W Shafer et al. Nucleic Acids Res. .

Abstract

The HIV RT and Protease Sequence Database is an online relational database that catalogs evolutionary and drug-related human immunodeficiency virus (HIV) reverse transcriptase (RT) and protease sequence variation (http://hivdb.stanford.edu). The database contains a compilation of nearly all published HIV RT and protease sequences including International Collaboration database submissions (e.g., GenBank) and sequences published in journal articles. Sequences are linked to data about the source of the sequence sample and the antiretroviral drug treatment history of the individual from whom the isolate was obtained. The database is curated and sequences are annotated with data from >230 literature references. Users can retrieve additional data and view alignments of sequence sets meeting specific criteria (e.g., treatment history, subtype, presence of a particular mutation). A gene-specific sequence analysis program, new user-defined queries and nearly 2000 additional sequences were added in 1999.

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Figures

Figure 1
Figure 1
Schema of HIV RT and Protease Sequence Database. The 17 rectangles (entities) depict 12 of the base tables in the database. Within the tables, the attributes (fields) are listed. The multiplicities of the linkages are demonstrated by either a 1 or an M (many). The schema demonstrates the hierarchical relationship between patients, patient-dates, isolates and sequences.
See this image and copyright information in PMC

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