doi: 10.1007/BF00291943.
Certain patterns of karyotype evolution in chronic myelogeneous leukaemia. Chromosome abnormalities in CML
- PMID: 1059629
- DOI: 10.1007/BF00291943
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Certain patterns of karyotype evolution in chronic myelogeneous leukaemia. Chromosome abnormalities in CML
Humangenetik.
.
Abstract
The study of chromosome banding pattern of leukaemic cells in 15 patients with CML revealed t(9;22) in all cases. Similar additional chromosome abnormalities were observed in the terminal stage of the disease in 5 of 9 patients with aneuploid cell lines. The most frequent abnormalities were i(17q) and trisomy 8. The regularities of karyotype evolution in the terminal stage of CML are discussed.
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