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. 1999 Nov;54(5):524-6.
doi: 10.1034/j.1399-0039.1999.540511.x.

DQB1*0602 confers genetic susceptibility to multiple sclerosis in Afro-Brazilians

A Caballero  1 , S Alvés-León, R Papais-Alvarenga, O Fernández, G Navarro, A Alonso
Affiliations

DQB1*0602 confers genetic susceptibility to multiple sclerosis in Afro-Brazilians

A Caballero et al. Tissue Antigens. 1999 Nov.

Abstract

We studied the distribution of the HLA-DRB1, -DQA1 and -DQB1 alleles in 44 Afro-Brazilian patients with multiple sclerosis and 88 controls. Although no significant differences were found between the patients and controls for the DRB1 and DQA1 alleles, the HLA-DQB1*0602 allele was positively associated with multiple sclerosis (45.0% vs. 17.0%, Pc=0.024, RR=3.31). The positive extended haplotypes for DQB1*0602 were more frequent in patients than controls, although the differences were not statistically significant in any of them. These results in Afro-Brazilians are in line with other studies which have found DQB1*0602 to be associated with the disease in the absence of the DRB1*1501 allele. We therefore think that the association with the disease in this ethnic group is more allelic than haplotypic.

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