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. 1999 Dec 17;286(5448):2345-8.
doi: 10.1126/science.286.5448.2345.

Evolution of shape complementarity and catalytic efficiency from a primordial antibody template

J Xu  1 , Q Deng, J Chen, K N Houk, J Bartek, D Hilvert, I A Wilson
Affiliations

Evolution of shape complementarity and catalytic efficiency from a primordial antibody template

J Xu et al. Science. .

Abstract

The crystal structure of an efficient Diels-Alder antibody catalyst at 1.9 angstrom resolution reveals almost perfect shape complementarity with its transition state analog. Comparison with highly related progesterone and Diels-Alderase antibodies that arose from the same primordial germ line template shows the relatively subtle mutational steps that were able to evolve both structural complementarity and catalytic efficiency.

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