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. 1975 Nov;72(11):4409-13.
doi: 10.1073/pnas.72.11.4409.

Fusion of dipalmitoylphosphatidylcholine vesicle membranes induced by concanavalin A

J van der Bosch, M McConnell

Fusion of dipalmitoylphosphatidylcholine vesicle membranes induced by concanavalin A

J van der Bosch et al. Proc Natl Acad Sci U S A. 1975 Nov.

Abstract

The temperature dependence of fatty acid spin label resonance spectra and freeze fracture micrographs of sonicated dipalmitoylphosphatidylcholine vesicles in the absence and presence of concanavalin A demonstrate a strong interaction of concanavalin A with these lipid membranes, which results in fusion of the vesicles. The rate of this reaction as followed with use of magnetic resonance exhibits a pronounced maximum at 36 degrees, the midpoint of the phase transition range of dipalmitoylphosphatidylcholine vesicles. This maximum is discussed in terms of structural fluctuations, which are maximal in the phase transition range of the membranes.

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References

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