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Review
. 1999 Dec 13;147(6):1123-8.
doi: 10.1083/jcb.147.6.1123.

Axonal control of oligodendrocyte development

B A Barres  1 , M C Raff
Affiliations
Review

Axonal control of oligodendrocyte development

B A Barres et al. J Cell Biol. .
No abstract available

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Figures

Figure 1
Figure 1
A model for how oligodendrocyte number is matched to axonal surface area. Once an OPC stops dividing and differentiates into an oligodendrocyte (left side of figure), it has 2–3 d to contact an unmyelinated region of axon, which provides a new signal that the cell requires for continued survival. Astrocyte-derived signals, such as PDGF, can promote the survival of newly formed oligodendrocytes for at least 2 d (middle of figure). But as the newly formed oligodendrocytes undergo further maturation (right side of figure), they lose responsiveness to these astrocyte-derived signals and require an axonal signal to survive. Those that fail to contact an axon by 3 d after generation undergo apoptosis.
See this image and copyright information in PMC

References

    1. Abney E.R., Bartlett P.P., Raff M.C. Astrocytes, ependymal cells, and oligodendrocytes develop on schedule in dissociated cell cultures of embryonic rat brain. Dev. Biol. 1981;83:301–310. - PubMed
    1. Acheson A., Conover J.C., Fandl J.P., DeChiara T.M., Russell M., Thadani A., Squinto S.P., Yancopoulos G.D., Lindsay R.M. A BDNF autocrine loop in adult sensory neurons prevents cell death. Nature. 1995;374:450–453. - PubMed
    1. Barres B.A., Raff M.C. Proliferation of oligodendrocyte precursor cells depends on electrical activity in axons. Nature. 1993;361:258–260. - PubMed
    1. Barres B.A., Raff M.C. Control of oligodendrocyte number in the developing rat optic nerve. Neuron. 1994;12:935–942. - PubMed
    1. Barres B.A., Hart I.K., Coles H.S., Burne J.F., Voyvodic J.T., Richardson W.D., Raff M.C. Cell death and control of cell survival in the oligodendrocyte lineage. Cell. 1992;70:31–46. - PubMed