Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1999 Dec 3;38(23):3418-3438.
doi: 10.1002/(sici)1521-3773(19991203)38:23<3418::aid-anie3418>3.0.co;2-v.

Absolute Asymmetric Synthesis: The Origin, Control, and Amplification of Chirality

BL Feringa  1 , van Delden RA
Affiliations

Absolute Asymmetric Synthesis: The Origin, Control, and Amplification of Chirality

BL Feringa et al. Angew Chem Int Ed Engl. .

Abstract

Biomolecular homochirality, the origin of which is still a puzzle, has challenged scientists to design chemical systems that provide chiral molecules through absolute asymmetric synthesis and to amplify a small stereochemical bias in such systems. The photoresolution of the enantiomers of helical-shaped, sterically overcrowded alkene 1 with circularly polarized light and the transduction of the stereochemical information by triggering the helical arrangement of a large collection of achiral molecules in a twisted nematic liquid crystalline phase (2) are examples of control and amplification of chirality.

PubMed Disclaimer

LinkOut - more resources