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Review
. 1999 May;1(6):437-43.
doi: 10.1016/s1286-4579(99)80047-1.

The pathogenesis of Acanthamoeba keratitis

J Y Niederkorn  1 , H Alizadeh, H Leher, J P McCulley
Affiliations
Free article
Review

The pathogenesis of Acanthamoeba keratitis

J Y Niederkorn et al. Microbes Infect. 1999 May.
Free article

Abstract

Free-living amoebae of the genus Acanthamoeba produce a progressive, blinding infection of the corneal surface. The pathogenesis of Acanthamoeba keratitis involves parasite-mediated cytolysis and phagocytosis of corneal epithelial cells and induction of programmed cell death. Acanthamoeba spp. elaborate a variety of proteases which may facilitate cytolysis of the corneal epithelium, invasion of the extracellular matrix, and dissolution of the corneal stromal matrix.

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