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Comparative Study
. 2000 Jan;44(1):186-9.
doi: 10.1128/AAC.44.1.186-189.2000.

Postantibiotic effects of grepafloxacin compared to those of five other agents against 12 gram-positive and -negative bacteria

S K Spangler  1 , S Bajaksouzian, M R Jacobs, P C Appelbaum
Affiliations
Comparative Study

Postantibiotic effects of grepafloxacin compared to those of five other agents against 12 gram-positive and -negative bacteria

S K Spangler et al. Antimicrob Agents Chemother. 2000 Jan.

Abstract

The postantibiotic effect (PAE) (10x the MIC) and the postantibiotic sub-MIC effects (0.125, 0.25, and 0.5x the MIC) were determined for six compounds against 12 strains. Measurable PAEs ranged between 0 and 1.8 h for grepafloxacin, 0 and 2.2 h for ciprofloxacin, 0 and 3. 1 h for levofloxacin, 0 and 2.2 h for sparfloxacin, 0 and 2.4 h for amoxicillin-clavulanate and 0 and 4.8 h for clarithromycin. Reexposure to subinhibitory concentrations increased the PAEs against some strains.

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