Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2000 Jan;44(1):186-9.
doi: 10.1128/AAC.44.1.186-189.2000.

Postantibiotic effects of grepafloxacin compared to those of five other agents against 12 gram-positive and -negative bacteria

S K Spangler  1 , S Bajaksouzian, M R Jacobs, P C Appelbaum
Affiliations
Comparative Study

Postantibiotic effects of grepafloxacin compared to those of five other agents against 12 gram-positive and -negative bacteria

S K Spangler et al. Antimicrob Agents Chemother. 2000 Jan.

Abstract

The postantibiotic effect (PAE) (10x the MIC) and the postantibiotic sub-MIC effects (0.125, 0.25, and 0.5x the MIC) were determined for six compounds against 12 strains. Measurable PAEs ranged between 0 and 1.8 h for grepafloxacin, 0 and 2.2 h for ciprofloxacin, 0 and 3. 1 h for levofloxacin, 0 and 2.2 h for sparfloxacin, 0 and 2.4 h for amoxicillin-clavulanate and 0 and 4.8 h for clarithromycin. Reexposure to subinhibitory concentrations increased the PAEs against some strains.

PubMed Disclaimer

References

    1. Child J, Andrews J M, Wise R. Pharmacokinetics and tissue penetration of the new fluoroquinolone grepafloxacin. Antimicrob Agents Chemother. 1995;39:513–515. - PMC - PubMed
    1. Cook P J, Andrews J M, Wise R, Honeybourne D, Moudgil H. Concentrations of OPC-17116, a new fluoroquinolone antibacterial, in serum and lung compartments. J Antimicrob Chemother. 1995;35:317–326. - PubMed
    1. Craig W A, Gudmundsson S. Postantibiotic effect. In: Lorian V, editor. Antibiotics in laboratory medicine. Baltimore, Md: The Williams & Wilkins Co.; 1996. pp. 296–329.
    1. Doern G V, Brueggeman A, Holley H P, Jr, Rauch A M. Antimicrobial resistance of Streptococcus pneumoniae recovered from outpatients in the United States during the winter months of 1994 to 1995: results of a 30-center national surveillance study. Antimicrob Agents Chemother. 1996;40:1208–1213. - PMC - PubMed
    1. Doern G V, Brueggeman A B, Pierce G, Holley H P, Jr, Rauch A. Antibiotic resistance among clinical isolates of Haemophilus influenzae in the United States in 1994 and 1995 and detection of β-lactamase-positive strains resistant to amoxicillin-clavulanate: results of a national multicenter surveillance study. Antimicrob Agents Chemother. 1997;41:292–297. - PMC - PubMed

Publication types

MeSH terms

LinkOut - more resources