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Clinical Trial
. 2000 Jan;44(1):207-9.
doi: 10.1128/AAC.44.1.207-209.2000.

Bioavailability of aciclovir after oral administration of aciclovir and its prodrug valaciclovir to patients with leukopenia after chemotherapy

H Steingrimsdottir  1 , A Gruber, C Palm, G Grimfors, M Kalin, S Eksborg
Affiliations
Clinical Trial

Bioavailability of aciclovir after oral administration of aciclovir and its prodrug valaciclovir to patients with leukopenia after chemotherapy

H Steingrimsdottir et al. Antimicrob Agents Chemother. 2000 Jan.

Abstract

The median bioavailabilities of aciclovir after administration of aciclovir and its prodrug valaciclovir were 21.5 and 70.1%, respectively, in 12 patients with malignant hematological diseases with leukopenia after chemotherapy. The interindividual variations of the bioavailability were 48.5 and 21.0% after administration of aciclovir and valaciclovir, respectively. Neither the bioavailability nor the interindividual variation of area under the concentration-time curve of oral aciclovir or valaciclovir differed from that reported in healthy volunteers.

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Figures

FIG. 1
FIG. 1
AUCs of aciclovir in relationship to patient age. (a) Aciclovir (400 mg) given as a 1-h infusion (rs = 0.91, P < 0.0001); (b) oral administration of 400 mg of aciclovir (rs = 0.18, P = 0.59); (c) oral administration of 500 mg of valaciclovir (rs = 0.68, P = 0.015).
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References

    1. Al-Yamani M, Al-Khamis J K I, El-Sayed Y M, Bawazir S A, Al-Rashood K A, Gouda M W. Comparative bioavailability of two tablet formulations of aciclovir in healthy volunteers. Int J Clin Pharmacol Ther. 1998;36:222–226. - PubMed
    1. Blum M R, Liao S H T, de Miranda P. Overview of aciclovir pharmacokinetic disposition in adults and children. Am J Med. 1982;73(Suppl. 1A):186–192. - PubMed
    1. Boxenbaum H G, Riegelman S, Elashoff R M. Statistical estimations in pharmacokinetics. J Pharm Biopharm. 1974;2:123–148. - PubMed
    1. De Miranda P, Blum M R. Pharmacokinetics of aciclovir after intravenous and oral administration. J Antimicrob Chemother. 1983;12(Suppl. B):29–37. - PubMed
    1. Dunne A. JANA: a new iterative polyexponential curve stripping program. Computer Methods Programs Biomed. 1985;20:269–275. - PubMed

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