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Review
. 1999 Aug;58(3):609-13.
doi: 10.1017/s0029665199000798.

A genetic dissection of the retinoid signalling pathway in the mouse

M Mark  1 , N B Ghyselinck, O Wendling, V Dupé, B Mascrez, P Kastner, P Chambon
Affiliations
Review

A genetic dissection of the retinoid signalling pathway in the mouse

M Mark et al. Proc Nutr Soc. 1999 Aug.

Abstract

To determine the functions of retinoic acid receptors RAR and RXR, we have systematically knocked-out their genes by homologous recombination in the embryonic stem cells and generated null-mutant mice. This approach has allowed us to perform a genetic dissection of the retinoic acid signalling pathway.

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